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Abstract #3808

Comparative evaluation of DTI and FLAIR images in assessment of whole pathological region in GBM patients for RT planning; a semi-automatic segmentation approach

Manijeh Beigi1, Mojtaba Safari1, Ahmad Ameri2, Mohsen ShojaeeMoghadam3, and Hamidreza SalighehRad1

1Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Institute for Advanced Medical Imaging, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 2Clinical Oncology, Shahid Beheshti University of Medical Science, Tehran, Iran (Islamic Republic of), 3Payambaran Imaging Center, Tehran, Iran (Islamic Republic of)

Accurate determination of whole pathological region is still a challenging task and necessary prerequisite step in radiotherapy planning in GBM. This study attempted to propose semi-automatic segmentation method that can extract whole pathogenic tumor on T2-FLAIR and isotropic component (p-map) of diffusion tensor imaging(DTI) with over 90 % sensitivity, specificity and dice score. In addition, the extension of pathological region was compared. Results show that there is significant difference between segmented region on T2-FLAIR and p map. Beyond usual segmentation method for T2-FLAIR, we have highlighted DTI parametric maps because of its information on tumor infiltration.

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