PIRADS-2 compliant Apparent Diffusion Coefficient mapping (ADC) and T2-weighted imaging was performed at baseline and week 6 of radiotherapy in 57 patients with localized prostate cancer. 101 radiomics features were calculated across the gross tumor volume (GTV) and whole prostate (WP). GTV ADC histogram metrics (10 percentile, median, mean) increased (p<1e-06) at equivalent maximum ADC values. High percentile WP ADC histogram metrics (90 percentile, maximum) decreased (p<2e-05) at equivalent 10 percentile/median/mean values. Between 44 (for GTV ADC) and 65 (for WP applied to T2w-weighted images) radiomics features were significantly different and will be explored as potential early predictive biomarkers of response.