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Abstract #3822

The effect of flow suppression on BOLD MRI of lung tumor

Heling Zhou1, Olivier Belzile2, Zhang Zhang3, Jo Wagner1, Chul Ahn4, James Richardson5, Debabrata Saha3, Rolf A Brekken6, and Ralph P Mason1

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, 4Clinical Science, UT Southwestern Medical Center, Dallas, TX, United States, 5Pathology, UT Southwestern Medical Center, Dallas, TX, United States, 6Surgery, UT Southwestern Medical Center, Dallas, TX, United States

Blood oxygen level dependent (BOLD) MRI is used to provide information on tumor oxygenation. However, the measurements are susceptible to blood flow changes, which often occur during hyperoxic gas challenge. This study investigated the extent of flow sensitivity by comparing BOLD measurements with and without flow suppression using two orthotopic lung xenograft tumor models. Flow suppression was found to affect multiple measurements including ΔSI(%) and R2*. The range of discrepancy was smaller in R2* than the ΔSI(%). High similarity was found in spatial patterns. ROI and spatial pattern analysis showed higher sensitivity to flow in A549 tumors than H460 tumors.

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