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Abstract #3834

Monitoring the Growth of Individual Tumours in the Mouse Lung using Cardio-Respiratory Synchronised bSSFP MRI

Ana L. Gomes1, Paul Kinchesh1, Danny Allen1, Veerle Kersemans1, Stuart Gilchrist1, Luiza Madia-Lourenco2, Anderson Ryan2, and Sean C. Smart1

1CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 2Department of Oncology, University of Oxford, Oxford, United Kingdom

bSSFP imaging is used in-vivo to image small tumours in the mouse lung, at an isotropic resolution of 200┬Ám in under 10 minutes per scan. Cardio-respiratory synchronisation using prospective gating control is used to minimise motion artefacts efficiently, and a 4 step RF phase cycle is used to eliminate banding artefact. Growth of individual tumours in multi-focal lung cancer can be measured with a throughput of >4 mice per hour.

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