The commonly observed relative signal increase of choline-containing compounds (tCho) in 1H MR spectra of tumors may serve as a diagnostic biomarker. Here we evaluate the potential of this tCho signal in 1H MR spectra of the human liver to assess metastases of colorectal cancers. An increased tCho signal was not observed for these metastases. With increasing tumor volumes, the tissue levels of tCho decreased. The likely reason is a larger necrotic voxel fraction as it correlated with more higher ADC values assessed by diffusion weighted imaging. A Bland-Altman analysis revealed average repeatability in normal livers and poor repeatability in tumors.