Abstract #3864

Assessment of Bound Sodium using Triple Quantum Selection vs. Inversion Recovery at 21.1 T

Nastaren Abad^1,2, Ghoncheh Amouzandeh^2,3, Jens T. Rosenberg², Michael G. Harrington⁴, and Samuel Colles Grant^1,2

¹Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, ²Center for Interdisciplinary MR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, ³Physics, Florida State University, Tallahassee, FL, United States, ⁴Huntington Medical Research Institutes, Pasadena, CA, United States

This study evaluates Triple Quantum (TQ) and Inversion Recovery (IR) techniques at 21.1 T with regards to bound sodium quantification. Using both gel phantoms imitating physiological concentrations/bound fractions as well as in vivo animal pathological models, the efficiency, SNR and selectivity of ²³Na TQ and IR techniques were compared with the ultimate goal of localizing specific sodium changes within intra- and extracellular compartments related to disease progression.

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