Abstract #3882

The effects of iodinated CT contrast agent on phosphorus MRS

Ladislav Valkovic^1,2, Justin YC Lau^1,3, Ines Abdesselam¹, Oliver Rider¹, Damian J Tyler^1,3, Christopher T Rodgers^1,4, and Jack JJJ Miller^1,3,5

¹Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sceinces, Bratislava, Slovakia, ³Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, ⁴The Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, ⁵Department of Physics, University of Oxford, Oxford, United Kingdom

Contrast-enhanced CT examination can influence ¹H-MRI measurements performed within 24h after the CT scan, due to a reduction in water T₁ and T₂ caused by the iodinated contrast agents used in CT. We have investigated whether contrast from a previous CT examination would also influence metabolic measurements made using ³¹P-MRS, by measuring the T₁ of ¹H and ³¹P signals in human blood. We find that iodinated CT contrast agent has no effect on phosphorus T₁s. Therefore, ³¹P-MRS examinations will not be influenced by prior CT (unlike ¹H-MRI scans).

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