Abstract #3889

Metabolite concentration changes associated with positive and negative BOLD signal in the human visual cortex: a functional magnetic resonance spectroscopy study at 7T.

Yohan Boillat¹, Lijing Xin², Wietske Van der Zwaag^2,3, and Rolf Gruetter^1,2,4,5

¹LIFMET, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²CIBM, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, ⁴Department of Radiology, University of Geneva, Geneva, Switzerland, ⁵Department of Radiology, University of Lausanne, Lausanne, Switzerland

The metabolite correlates of the negative BOLD signal were investigated using functional MRS and compared to the changes produced by the positive BOLD response. The participants were scanned in a 7-T MRI while passively viewing visual checkerboards. For the positive BOLD response, increases of glutamate and lactate concentrations were observed, while the negative BOLD response in a similar voxel was linked to a decrease of glutamate, lactate and GABA concentrations. This measured decrease of oxidative metabolism during the negative BOLD response suggest a reduction a glutamatergic activity in the visual cortex.

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