Astrocytic metabolism is impaired in many central nervous system diseases, like obesity or diabetes. Using 1H-[13C] MRS together with [2-13C]acetate infusion in a 14.1T magnet, we have measured the incorporation of 13C labeling in the mouse hypothalamus in vivo, and calculated its metabolic fluxes using a two-compartment metabolic model that distinguishes between neurons and astrocytes. We think that these results open the possibility of investigating local variations of astrocytic metabolism in the mouse hypothalamus in vivo.
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