Abstract #3912

Synthetic MRI of bone metastases in castration-resistant prostate cancer: detection of tumor activity and calcifications.

Yuki Arita^1,2, Taro Takahara³, Soichiro Yoshida⁴, Thomas C Kwee⁵, Tatsuaki Kobayashi⁶, Chikako Ishii⁷, Jun Kurasawa⁷, Kazuya Sugimoto³, Nobuya Higuchi^1,2, and Yasuhisa Fujii⁴

¹Department of Radiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan, ²Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan, ³Department of Biomedical Engineering, Tokai University School of Engineering, Kanagawa, Japan, ⁴Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan, ⁵Department of Radiology, UMC Groningen, Groningen, Netherlands, ⁶Visionary Imaging Services, Inc., Yokohama, Japan, ⁷Department of Radiology, Advanced Imaging Center Yaesu Clinic, Tokyo, Japan

We quantified T1, T2, and proton density (PD) of bone metastases in castration-resistant prostate cancer with synthetic MRI (SyMRI). Bone foci of interest were classified into four groups; active disease, red bone marrow (RBM), inactive disease without calcification (Inactive C(-)), and inactive disease with calcification (Inactive C(+)). Active disease group showed very high PD, and Inactive C(+) group showed very low PD. Both Inactive C(-) and RBM showed medium values. Significant differences were noted among these three divisions. SyMRI thus shows clinical potential to differentiate active/inactive lesions, calcifications, and red bone marrow in castration-resistant prostate cancer.

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