Abstract #3921

Development of a Patient-specific Tumor Mold using MRI and 3D Printing Technology for Targeted Tissue Procurement and Radiomics Analysis of Renal Masses

Durgesh Kumar Dwivedi¹, Yonatan Chatzinoff¹, Qing Yuan¹, Jeffrey A. Cadeddu^1,2, Payal Kapur^2,3, and Ivan Pedrosa^1,2,4

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Urology, UT Southwestern Medical Center, Dallas, TX, United States, ³Pathology, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

To implement a platform for co-localization of in vivo quantitative multi-parametric magnetic resonance imaging (mpMRI) features with ex vivo surgical specimens of patients with renal masses using patient-specific 3D-printed tumor molds, which may aid in targeted tissue procurement and radiomics/radiogenomic analyses. Volumetric segmentation of 6 renal masses was performed with 3D Slicer (http://www.slicer.org) to create a three-dimensional (3D) tumor model. All patients successfully underwent partial nephrectomy and adequate fitting of the tumor specimens within the 3D mold was achieved in all tumors. Distinct in vivo MRI features corresponded to unique pathologic characteristics in the same tumor.

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