We investigate the ability of perfusion MRI to probe glioblastoma infiltration into healthy brain tissue, on a patient-derived mouse model presenting infiltrative tumour margins. Using a high SNR Arterial Spin Labelling sequence and a multiple slice in-plane histology method, we show that perfusion imaging can probe lower tumour cell density regions than conventional MRI. Voxel-to-voxel comparison between perfusion and tumour cell density images, allows identifying a negative relation between tumour cell burden and perfusion at the invasion margins. This relation, related to vascular co-option mechanisms, could be used as a marker of tumour cell infiltration into healthy tissue.
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