Meeting Banner
Abstract #3937

Locally constrained registration of dynamic contrast enhanced MRI time series improves tracer kinetic model voxel-wise fit repeatability in liver tumours

Michael Berks1, Ross A Little1, Yvonne Watson1, Sue Cheung1, Gordon C Jayson2, James P B O'Connor2,3, and Geoff J M Parker1

1Division of Informatics, Imaging & Data Sciences, University of Manchester, Manchester, United Kingdom, 2Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 3CRUK & EPSRC Cancer Imaging Centre in Cambridge and Manchester, Cambridge and Manchester, United Kingdom

DCE-MRI enables the estimation of clinically useful parameters of tissue microvasculature, and is frequently used in trials of anti-angiogenic drugs. However tissue movement can lead to inaccurate parameter estimation. Rapidly changing contrast and limited spatial structure within tumours makes DCE-registration a challenging task. We present a novel algorithm that estimates a model of local tumour motion from the most stable part of the time-series and uses this to constrain registration of the whole series. We demonstrate statistically significant improved extended Kety-model fits and improved parameter repeatability for a set of 59 liver tumours in 40 patients, at two baseline scans.

This abstract and the presentation materials are available to members only; a login is required.

Join Here