Low concentration metabolites with J-coupled peaks are difficult to quantify using MRS, even using MEGA-PRESS or its recently propose HERMES implementation. Using LCModel with simulated basis sets can lead to inaccurate metabolite quantification, since the spatial-dependence of the signal is often not fully accounted for. This can be minimised by increasing the number of spatial positions simulated, at the expense of computation time. We simulated basis sets for MEGA-PRESS and HERMES using the recently introduced approach based on one-dimension projections, as a replacement for the commonly used three-dimensional method, providing more accurate basis sets in shorter computation time.
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