Meeting Banner
Abstract #4001

Detection of 5-Fluorouracil (5-FU) Tumor Trapping Using Fluorine-19 Chemical Shift Imaging in a Murine Model of Colorectal Cancer

Yurii Shepelytskyi1, Karen Davenport2, Matthew S Fox3, Tao Li2, Mitchell Albert1,2,4, and Eric Davenport5

1Chemistry, Lakehead University, Thunder Bay, ON, Canada, 2Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 3Medical Biophysics, University of Western Ontario, London, ON, Canada, 4Northern Ontario School of Medicine, Thunder Bay, ON, Canada, 5Thunder Bay Regional Health Science Centre, Thunder Bay, ON, Canada

Colorectal cancer is an increasing healthcare problem and is the third leading cause of cancer deaths worldwide. Fluorine-19 (19F) chemical shift imaging (CSI) can detect the distribution of 5-fluorouracil (5-FU) and its metabolites within a tumor over time. By measuring the 5-FU trapping, it is possible to determine the tumor response at the earliest stage of treatment (before changes in tumor size are observable). In this work, we present preliminary results of detecting the presence and absence of 5-FU trapping in mice bearing H-508 and HT-29 colorectal tumors, respectively.

This abstract and the presentation materials are available to members only; a login is required.

Join Here