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Abstract #4005

Effects of Fraction of Inhaled Oxygen on Hyperpolarized 129Xe MR Signals Acquired from the Rat Brain In Vivo

Yonni Friedlander1,2, Marcus Couch1,2, Andrea Kassner1,3, and Giles Santyr1,2

1Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Medical Imaging, University of Toronto, Toronto, ON, Canada

A theoretical model was developed to describe the dependence of the signal strength of 129Xe dissolved in the rat brain on the fraction of inhaled oxygen (FiO2). To validate the model, 129Xe MR signals were measured in the rat brain in vivo for four different values of FiO2 using a continuous ventilation scheme. The measured 129Xe RBC signal showed a strong dependence on FiO2 in good agreement with the trends predicted by the theoretical model. These results underscore the need to optimize and control FiO2 when using 129Xe signals to probe brain function.

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