Primary hypothermia/cold stress is due to environmental exposure, with no underlying medical condition causing disruption of temperature regulation. The exposure of human to such conditions often leads to decremented physical and mental performance. Metabonomics can provide a quick snapshot of exogenous/endogenous stressors induced metabolic perturbations. The metabolic pathways analysis showed that Taurine and TCA metabolism have maximum contribution to the altered urine metabolic phenotype. Metabolic markers related to liver dysfunction, gut microflora & muscle bioenergetics were altered due to cold exposure. These changes in combination with genomics and proteomics studies would further reveal potential drug targets contributing to cold exposure medicine.