The intestinal protozoan parasite Giardia lamblia is a major cause of persistent diarrhea in humans and animals worldwide. Details concerning underlying metabolic pathways in Giardia are scarce and a methodology to study giardial intermediary and energy metabolism is required. Here, a high resolution magic angle spinning (HR-MAS) NMR study is presented determining the metabolic profile of G. lamblia trophozoites. This study builds the basis of following investigations on Giardia that are resistant against Metronidazole and other nitro compounds, which have been used since decades as therapy of choice against giardiasis.
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