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Abstract #4017

Oxidative Stress and Neurotransmitters Imbalance in Amyotrophic Lateral Sclerosis

Mona Adel Mohamed1, Muhammad Saleh1, Mark Mikkelsen 1, Kristen Riley2, Jeffrey Rothstein2, Lora Clawson2, Peter B Barker1, and Richard AE Edden1

1Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, United States, 2Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, United States

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and invariably fatal motor neuron disease. The objective of the study was to use the newly developed HERMES (Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy) spectral editing methodology to simultaneously measure key compounds related to oxidative stress and glutamatergic metabolism (GSH, GABA, and Glx) in patients with ALS and control subjects. Using HERMES, we were able to look at different metabolic pathways in ALS in one MRS session. Improved understanding of the various metabolic pathways in ALS will lead to the development of new diagnostic surrogate markers and therapeutic approaches.

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