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Abstract #4043

Synergistic effect of MR-HIFU hyperthermia mediated drug delivery followed by ablation

Edwin Heijman1, Nicole Hijnen2, Esther Kneepkens2, Mariska de Smet2, Sander Langereis3, and Holger Gr├╝ll4

1Oncology Solutions, Philips Research, Cologne, Germany, 2Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 3Oncology Solutions, Philips Research, Eindhoven, Netherlands, 4Department of Radiology, Experimental Imaging and Image-guided Therapy, University Hospital of Cologne, Cologne, Netherlands

Four Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) thermal therapy strategies (no HIFU, hyperthermia, ablation and hyperthermia followed by ablation) in combination with temperature sensitive liposomes (TSLs), co-encapsulating doxorubicin (dox) and ProHance®, were investigated in rhabdomyosarcoma rat tumor model. All HIFU heating strategies combined with TSLs resulted in cellular uptake of dox deep into the interstitial space and significant increase of intratumoral drug concentrations. The combination of hyperthermia-triggered TSLs followed by ablation showed the best therapeutic outcome compared to other strategies due to direct induction of thermal necrosis in the tumor core and efficient drug delivery to the tumor rim.

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