Hyperthermia has been shown in clinical trials to strongly enhance therapeutic efficacy of radio- and chemotherapy. The main challenge in hyperthermia is to achieve spatially homogenous temperatures between about 41-43 oC for ca. one hour. Magnetic Resonance Imaging-guided High Intensity Focussed Ultrasound (MR-HIFU) enables heating of tissues with high spatial accuracy. We developed a new regulatory algorithm based on Model Predictive Control (MPC) for stable MR-HIFU-hyperthermia, which is designed to find effective heating patterns based on predictions of the temperature evolution in tissue. A comparison with the currently available controller is presented, detailing advantages, shortcomings and opportunities.