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Abstract #4171

Assessment of Immediate Response to Irreversible Electroporation for Targeted Ablation of Liver Tissues Using Dynamic Contrast Enhancement in a Rabbit Model

Junjie Shangguan1,2, Matteo Figini1, Chong Sun1,3, Liang Pan1,4, Bin Wang1,5, Quanhong Ma1, Kang Zhou1,6, Na Shang1, and Zhuoli Zhang1

1Department of Radiology, Northwestern University, Chicago, IL, United States, 2Driskill Graduate Program, Northwestern University, Chicago, IL, United States, 3Orthopedics, Qilu Hospital, Shandong University, Jinan, China, 4Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China, 5General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, 6Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

Irreversible electroporation (IRE) may be visualized by MRI immediately post-procedure to monitor and assess tissue response peri-operatively. Dynamic contrast-enhanced MRI (DCE-MRI) allows measurement of tissue perfusion. We will demonstrate that DCE-MRI allows early visualization of IRE ablated tissue margins for prediction of the ablated region and quantification of tissue response. 6 rabbits underwent IRE ablation of the liver and pre-IRE and post-IRE DCE-MRI. A decrease in post-IRE apparent diffusion coefficients in the ablated region compared with baseline indicates tissue damage. Post-IRE AUC is decreased compared with baseline, suggesting decreased but still present blood perfusion in the ablated region post-IRE.

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