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Abstract #4192

Absence of T1 hyperintensity in the brain of high-risk iron loaded thalassemia patients after multiple administrations of high dose Gadobutrol

Antonella Meloni1, Domenico Montanaro1, Vincenzo Positano1, Daniele De Marchi1, Mariachiara Resta2, Petra Keilberg1, Laura Pistoia1, Anna Spasiano3, Tommaso Casini4, Caterina Cinzia De Bari5, Sara De Cori1, and Alessia Pepe1

1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2Policlinico Università di Bari, Bari, Italy, 3Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli", Napoli, Italy, 4Ospedale “Meyer”, Firenze, Italy, 5Ospedale "San Donato", Arezzo, Italy

Our study describes the lack of increased signal intensity (SI) in T1-weighted MRI images after repeated administrations of Gadobutrol in a high-risk population (high dose/scan, iron overload that facilitates the transmetallation of gadolinium). A potential role of the chelation therapy cannot be excluded. Moreover, it is highlighted that SI ratios in the sampled areas differ between 1.5T and 3T.

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