Multi-echo GRE sequence with bipolar readout gradients can reduce the achievable echo spacing compared to unipolar readout gradients for fat fraction (FF) quantification, and has higher acquisition efficiency. The eddy current induced phase (EC-phase) in bipolar sequence corrupts the phase consistency between the echoes, making it one of the confounding factors for the accurate fat quantification. In this study, we proposed an accurate EC-phase estimation method in bipolar acquisition sequence for FF quantification. The proposed method is validated through comparing the FF quantification from the EC-phase corrected bipolar data to the well-established unipolar acquisition through phantom experiments.
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