Theoretically, DKI and quantitative DCE-MRI can provide more precise microstructure and perfusion information of tissues. However, the two methods had rarely been reported in solitary pulmonary nodules (SPNs) to date, so we collected 37 patients with SPNs underwent both DKI and DCE-MRI and measured relative parameters. The Kapp, Ktrans, Ve and iAUC values were significantly higher in lung cancer than in benignity. Kapp had best sensitivity and accuracy, and iAUC had best specificity. The combination of both methods can provide a robust way to discriminate SPNs before clinical management.