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Abstract #4352

Dynamic contrast-enhanced MRI for the evaluation of perfusion heterogeneity in idiopathic pulmonary fibrosis

Nicholas David Weatherley1, Helen Marshall1, Paul Hughes1, Jody Bray1, David Capener1, Matthew Austin1,2, Laurie Smith1,3, Stephen Renshaw1, Stephen Bianchi2, and Jim Wild1

1University of Sheffield, Sheffield, United Kingdom, 2Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) produces metrics of lung perfusion at the capillary level. To date, little assessment of patients with idiopathic pulmonary fibrosis (IPF) has been reported with DCE-MRI. In fourteen patients with IPF, we found that regions of low flow and high transit times were associated with anatomical disease. Whole lung metrics of transit time and heterogeneity of blood volume demonstrated a relationship with pulmonary function tests. Such functional imaging strategies may be useful in quantifying functional changes in the pulmonary vasculature in IPF.

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