Intravoxel Incoherent Motion (IVIM) DWI was acquired with 13 b-values, ranging from 0 to 250 s/mm2. With such low b-values, a short TE results in a better signal-to-noise ratio. Monoexponential fitting was performed to obtain ADC, and biexponential fitting was performed to obtain diffusion D, perfusion fraction f, and perfusion related pseudo-diffusion coefficient D*. In a prostate cancer (PCa) patient cohort, we only found a significant difference between normal and tumor tissue for D, which was absent in ADC, f, and D*. This suggests that IVIM biexponential analysis can help remove perfusion component from diffusion, leading to a more accurate measurement in diffusion coefficient.