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Abstract #4452

Quantitative Predictors of Response to Neoadjuvant Chemotherapy on Dynamic Contrast-Enhanced Breast MRI

Hyung Won Choi1, Melissa Joines1, Anne Hoyt1, Laura Doepke1, Jane Dascalos1, Cheryce Fischer1, Nanette DeBruhl1, Nazanin Yaghmai1, Kara Lee Pool1, Bo Li1, James Sayre1, and Stephanie Lee-Felker1

1UCLA, Los Angeles, CA, United States

In this IRB-approved, HIPAA-compliant retrospective study, 63 consecutive women with newly diagnosed breast cancer undergoing neoadjuvant chemotherapy with pre- and post- chemotherapy breast MRI on a 3.0 Tesla scanner prior to surgery at our institution between January 2013 and December 2015 were included for analysis. Decrease in tumor size, decrease in peak enhancement, increase in time to peak, decrease in wash in, and decrease in wash out on post-chemotherapy breast MRIs were predictive of pathologic complete response on surgical pathology, a surrogate for prognosis.

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