Spiral-IDEAL is a fast and efficient technique for imaging dissolved-phase hyperpolarized 129Xe in tissue/blood plasma (T/P) and red blood cell (RBC) compartments of the lung. Previously, spiral-IDEAL has been limited to pre-clinical rodent models using multi-breath techniques not suitable for human subjects. In this work we optimize and demonstrate clinical translation of spiral-IDEAL for single breath-hold 129Xe imaging of human subjects. We compare and contrast several interleaved imaging strategies. Furthermore, we also demonstrate 3D spiral-IDEAL for simultaneous volumetric imaging of gas, T/P, and RBC compartments.