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Abstract #4508

The diagnostic potential and repeatability of Relative Enhanced Diffusivity (RED) as a biomarker for prostate cancer

Daniel Chen Billdal1, Mohammed R S Sunoqrot1, Kirsten Margrete Selnæs1,2, Peter Thomas While3, Brage Krüger-Stokke1,3, Helena Bertilsson4,5, Tone Frost Bathen1,2, and Mattijs Elschot1

1Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 2St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, 3Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, 4Department of Cancer Research and Molecular medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 5Department of Urology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

Relative Enhanced Diffusivity (RED) expresses the relative change in ADC between lower and higher b-value regimes. The purpose of this study was to investigate the diagnostic potential and repeatability of RED as a biomarker for prostate cancer (PCa).

Ten (10) healthy volunteers and 28 high-risk patients diagnosed with PCa underwent diffusion-weighted MRI. For the healthy volunteers, the repeatability of RED was good to acceptable. For the patients, RED was able to discriminate tumors from healthy tissue in the peripheral zone using either b=50 or b=400 mm/s2 as the intermediate b-value (p < 0.001).

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