Preclinical fMRI is often performed under general anesthesia which may compromise the brain reactivity but also interfere with the central effect of test compounds. We hereby performed a comparison of Isoflurane and propofol anesthetic regimens in order to determine the compatibility of both compounds with hyperalgesia induced by capsaicin. Threshold to reach robust somatosensory activation seems to be increased under propofol anesthesia but pain related activation remained at 44 degrees using both anesthetics. Capsaicin induced significant T2* changes in both groups but mismatches were observed suggesting different pathways to be involved and therefore prevail further investigation.
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