The purpose was to investigate the potential of IVIM model to quantify diffusion and perfusion in human placenta of normal pregnancy. The relation between Apparent diffusion coefficient ADC, perfusion fraction f and pseudo-diffusion coefficient D* obtained in fetal and maternal placenta with microstructural changes occurring during placenta development was investigated. 30 pregnant women (gestational age, GA range = 19-37w) underwent DW examination with b=0,10,30,50,75,100,150,400,700,1000s/mm2. The Pearson correlations between ADC, D*, f and clinical data (GA, Body-Mass Index and basal Glycaemia) were evaluated. ADCvsGA showed significant positive and negative correlation during the II and III trimester of gestation, respectively.