There is growing interest in applying functional MRI methods to patient studies, especially BOLD and Diffusion MRI in patients with chronic kidney disease. We have had the opportunity to analyze data from a multi-center trial involving patients with advanced CKD (stage 3B & 4) with multiple etiologies. A healthy control group was used to compare the patient cohort. Data shows small increase in cortical R2*, decrease in medullary R2* and response to furosemide in CKD. ADC was reduced in CKD and was correlated with medullary R2*.