This study aimed to evaluate the image quality and scan time of the simultaneous multi-slice (SMS) technique compared to integrated slice-by-slice shimming (iShim[MB1] ) single-shot echo planar imaging (ss-epi) for diffusion-weighted imaging (DWI) of the kidneys. Six healthy subjects and 22 patients with renal disease underwent both SMS and iShim DWI scans on a 3T MR scanner. Despite the average scan time of SMS DWI being decreased by 53.5% compared to iShim DWI, the image quality of SMS DWI was slightly better, with a higher signal-to-noise ratio and similar contrast-to-noise ratio. ADC values of the kidneys were comparable in both DWI sequences. [MB1]Our product name is "SliceAdjust".