Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transcatheter arterial chemoembolization (TACE) play an important role in treatment for HCC. Evaluation of the response to TACE treatment affects not only the therapeutic efficacy but also the treatment plan. Data from 43 patients with hepatic cancer between January 2017 and September 2017 were recruited for this study. Magnetic resonance imaging (MRI) and DKI (b=0, 800, 1500, 2000 mm2/s) were performed before and 3 weeks after initiating TACE. Contrast-enhanced MRI was performed 3 months and 6 months after initiating TACE. We observed a significant decrease in MK in HCC tissues that were completely necrotic after TACE. The MK value can reflect the complexity of tissue structure. A lower MK value indicates evidence of necrosis, implying more stable lesions and hence better treatment outcomes. Therefore, the differences in MK values observed in our study reflected the differences in tissue microstructural complexity between the progressing and non-progressing groups. The change of MK values before and after TACE can thus be used to estimate the degree of tumor necrosis and to further evaluate the effect of interventional therapy.