DWI is rapidly becoming a modality of choice to detect, characterize and monitor malignant lesions. Although diffusion imaging has benefited greatly from multiband imaging in the brain, investigation on abdomen DWI using MB has been limited. The purpose of this study was to examine the feasibility of MB-SENSE for abdominal DWI. The study demonstrated that MB-SENSE can be used to accelerate abdominal DWI with drastically reduced acquisition time (~50%) without having a significant impact on image quality. Though, refinement of the MB-SENSE free-breathing single-shot EPI sequence is necessary to ascertain the clinical value of MB-SENSE in DWI for the abdomen.