The simultaneous multi-slice (SMS) technique allows reducing the scan time of DWI without significant compromises in image quality. An adequate test-retest reliability of apparent diffusion coefficient (ADC) is essential for clinical use. The aim of this study was to prospectively compare the ADC value and test-retest repeatability of SMS-DWI with elastic in-plane motion correction in comparison to conventional DWI in healthy liver parenchyma. SMS-DWI and motion corrected SMS-DWI images (Moco-SMS) demonstrated significantly higher ADC values than conventional DWI in almost all liver regions. Moco-SMS showed significantly higher test-retest repeatability than conventional DWI in regions close to liver edges.