Abstract #4626

Prediction of treatment response based on baseline volumetric functional MR imaging criteria in patients with unresectable HCC who are candidate for Trans-Arterial Chemoembolization.

Mounes Aliyari Ghasabeh¹, Ankur Pandey², Sanaz Ameli², Pallavi Pandey², pegah Khoshpouri³, Yan luo³, Farnaz Najmi varzaneh⁴, Manijeh Zargham pour³, and Ihab R. Kamel³

¹John Hopkins Hospital, Baltimore, MD, United States, ²Johns Hopkins Hospital, Baltimore, MD, United States, ³Johns Hopkins Hospital, baltimore, MD, United States, ⁴johns Hopkins Hospital, Baltimore, MD, United States

Synopsis: Predicting overall survival in HCC patients before initiating treatment is essential to personalize a treatment plan for each patient. Barcelona clinic liver cancer (BCLC) is one of the current criteria for predicting pre-therapeutic overall survival (OS). Several studies suggested a valuable role of functional MRI biomarkers including diffusion-weighted imaging (DWI) with apparent diffusion coefficients (ADC), tumor venous enhancement (VE) and tumor volume (TV) in tumor response assessment. These metrics rely on changes post therapy; none of these parameters assessed baseline values of these variables in predicting OS before starting treatment.

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