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Abstract #4640

Resting state default-mode network functional connectivity correlates with Glutamate‚ÄČ+Glutamine/Creatine ratio of the medial prefrontal cortex in methamphetamine males : An fMRI-MRS study

Qiuxia Wu1, Chang Qi1, Yanhui Liao1, Jingsong Tang1, We Hao1, and Tieqiao Liu1

1Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, China

This study investigates the functional connectivity (FC) of medial prefrontal cortex (mPFC) within default mode network (DMN) and the ratio of Glutamate+Glutamine/Creatine (Glx/Cr) in male methamphetamine-dependent subjects (MADs). We combined functional magnetic resonance imaging and magnetic resonance spectroscopy to investigate the altered FC and its relation with ratio of Glx/Cr in 54 male MADs and 52 healthy male controls. We found increased FC of mPFC with left posterior cingulate cortex and the ratio of Glx/Cr and their negative relation in male MADs. Our results may help with investigation of MADs pathophysiology.

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