Linking the anatomy of neuronal connections to brain function is fundamental to our understanding of how brain architecture underpins human cognition. In this work, we hypothesized that the microstructural features of a white matter pathway relate to functional connectivity between the brain regions it connects. In a large cohort of subjects from UK Biobank, we demonstrate that the functional connectivity of homotopic brain regions from the two hemispheres can be predicted from the microstructure of the tract that connects them.
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