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Abstract #4661

Resting state DfMRI revealed alterations of brain activity and network in obsessive–compulsive disorder mouse model

Yoshifumi Abe1, Yuki Sakai2, Hiroaki Hamada3, Norio Takata1, Yuichi Hiraoka4, Tomomi Aida4, Kohichi Tanaka4, Kenji Doya3, and Kenji Tanaka1

1Departemnt of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan, 2ATR Brain Information Communication Research Laboratory Group, Kyoto, Japan, 3Neural Computation Unit and Biological Physics Theory unit, Okinawa Insititute of Science and Technology, Okinawa, Japan, 4Department of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Diffusion fMRI (DfMRI) is a powerful functional imaging method to investigate neural activity and network without BOLD confounding hemodynamic effects. In this study, we applied DfMRI to evaluate brain activity and network of neuropsychiatric disease model, obsessive–compulsive disorder (OCD). Our DfMRI study revealed that the cortex was excited and the hippocampus was inhibited. Functional connectivity analysis of DfMRI detected alterations of cortico-striatal-thalamic networks, in line with the previous study with OCD patients. Additionally, we found that interesting network alterations of the hippocampal networks in this OCD model mice.

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