It is critical to distinguish adenocarcinoma arising from uterine corpus or cervix due to their different treatment methods and prognosis. However, it is hard to make a definite diagnosis based on MRI morphological characteristics, clinical examination., even the biopsy in some cases. The tumor biological information can be quantitatively evaluated by ADC and IVIM parameters(such as D, D* and f). Our study showed that ADC, D and f were significantly lower in the endometrial adenocarcinoma than the cervical adenocancinoma. IVIM parameters are promising biomarkers in predicting tumor origin of the uterine adenocarcinoma which contribute to treatment planning and prognosis evaluation.