Abstract #4718

Increased small bowel permeability is associated with significantly increased T2 measures of the small bowel wall.

Hannah G Williams¹, Robert Scott^2,3, Luca Marciani^2,3, Catherine Ortori⁴, Guruprasad Aithal^2,3, Penny A Gowland^1,3, and Caroline L Hoad^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre at the Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, ³Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, ⁴Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom

Available techniques to measure in-vivo bowel permeability are inadequate for stratifying patients to identify those at risk of complications. T₂ weighted measurements in Crohn’s disease are sensitive markers of small bowel wall structural changes and could potentially be indicators of permeability. We have developed quantitative T₂ measures of the small bowel wall to characterize changes associated with increased permeability induced by indomethacin. We found a significant increase in quantitative measures of T₂ of the small bowel wall associated with increased permeability provoked by indomethacin.

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