In this study, 42 healthy male underwent a randomized, double blinded, parallel-group trial with either polyphenols or placebo during 31 days of high-carbohydrate and high-fat overfeeding. Changes in visceral, subcutaneous adipose tissue volumes and liver fat were measured using multi-gradient echo sequence. Visceral, subcutaneous adipose tissue volumes and liver fat increased significantly during overfeeding. The ratio VAT/SAT increased during overfeeding for the placebo group whereas this ratio slightly decreased for the polyphenol group.
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