In this preliminary study, we cross-validated the usefulness of multi-parametric MRI (fat fraction, liver stiffness, and damping ratio) in assessing the disease development and treatment response in both NASH and AH mouse models. Fat fraction has excellent agreement with the steatosis changes in both progressive and regressive AH and NASH models. In AH models, hepatic inflammation indicators have shown promising trends that well agreed each other in ALT and damping ratio. For the NASH model, both liver stiffness and damping ratio increased progressively in the fast-food-diet group, and the changes of stiffness was consistent with the end-point histology of fibrosis.
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