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Abstract #4749

Non-invasive MR-based blood oximetry via multi-parametric, non-linear estimation: initial multi-center experience in adult and pediatric patients

Juliet Varghese1, Lajja Desai2, Rizwan Ahmad1,3, Lee C Potter4, Ning Jin5, Cynthia K Rigsby2, Paul Tannous2, Aimee K Armstrong6, Michael Markl7, Kan N Hor6, Subha Raman1,8,9, and Orlando P Simonetti1,8,9

1Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States, 2Northwestern University School of Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 3Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, 4Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States, 5Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc, Columbus, OH, United States, 6The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States, 7Departments of Radiology and Biomedical Engineering, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 8Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States, 9Department of Radiology, The Ohio State University, Columbus, OH, United States

Non-invasive estimation of blood oxygen (O2) saturation by magnetic resonance (MR) imaging would be useful in evaluating shunt severity in congenital heart disease, and oxygen delivery and consumption energetics in heart failure and pulmonary hypertension. A T2-based, non-linear, multi-parameter method has been developed to non-invasively determine O2 saturation in the heart and great vessels. In this multi-center study, the feasibility and accuracy of the technique is evaluated against gold-standard catheterization measurements in the cardiac chambers and vessels in a preliminary cohort of adult and pediatric patients with cardiovascular disease.

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