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Abstract #4752

Accelerated Coronary 4D-Flow MRI: towards noninvasive functional assessment of stable coronary artery disease

Zixin Deng1, Michael Loecher2, Anthony Christodoulou1, Christopher Nguyen1, Zhengwei Zhou1, Jaime Shaw1, Yibin Xie1, Xiaoming Bi3, Zhaoyang Fan1, Daniel Ennis2, and Debiao Li1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 3Siemens Healthcare R&D, Los Angeles, CA, United States

In patients with suspected coronary artery disease (CAD), invasive catheterization is commonly used to determine the need for coronary revascularization. However, recent studies have shown that >50% of patients who undergo invasive catheterization have non-significant coronary lesions, hence the procedure was unnecessary. Recent work using 4D-Flow and the Navier-Stokes equations has shown promise for the noninvasive assessment of CAD, but still requires long scan times. This work explored coronary 4D-Flow using a stack-of-stars acquisition and compressed sensing to achieve 2-3x acceleration. The goal was to develop a more clinically feasible noninvasive pressure gradient measurement method for the assessment of CAD.

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