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Abstract #4809

Magnetic Susceptibility Mapping Reveals Altered Vein Oxygenation in Patients with Brain Arteriovenous Malformations: A Preliminary Study

Emma Biondetti1, Alvaro Rojas Villabona2,3, Hans Rolf J├Ąger4,5, David L Thomas6,7, and Karin Shmueli1

1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2The Gamma Knife Centre at Queen Square, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 3Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 4The Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 5Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, University College London, London, United Kingdom, 6Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom, 7Leonard Wolfson Experimental Neurology Centre, Institute of Neurology, University College London, London, United Kingdom

Arteriovenous malformations (AVMs) are vascular anomalies characterised by arteriovenous shunting with the lack of a capillary bed. Since the veins that drain an AVM contain arterialised blood, they would be expected to have a higher venous oxygen saturation (SvO2) than normal veins. Due to the paramagnetic properties of deoxyhaemoglobin, SvO2 can be calculated using magnetic susceptibility mapping (SM). Here, we calculated SM-based SvO2 in five patients with a brain AVM. We found higher SvO2 in the AVM draining veins compared to normal veins, showing that SM might be a valuable tool to study AVM physiology.

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