Debilitating fatigue is the most common consequence of stroke, however there are no known clinical or radiological biomarkers associated with post-stroke fatigue. We assessed differences in regional brain volumes obtained from T1-weighted, high-resolution structural scans between stroke survivors with and without severe fatigue. Differences were observed in the volume of the globus pallidus and putamen, as well as the ipsilesional temporal, parietal and frontal lobe. The mentioned morphological differences between stroke survivors with and without severe fatigue have also been reported in multiple sclerosis and Parkinson’s-related fatigue, suggesting a possible common mechanism.
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