The dynamic evolution of vascular impairment following thrombotic stroke has important clinical implications for designing effective management and treatment strategies. In the current study, we quantified the rate of water exchange across the blood-brain barrier (BBB) via water exchange index (WEI) in clinical patients undergone thrombectomy. Although extravasation of Gd-DTPA was not observed in most of the patients, the WEI was significantly elevated in both infarct and peri-infarct areas, revealing compromised integrity of the BBB.
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